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Her research primarily has focused on non-traditional actions of steroid hormones, in particular mechanisms of steroids that are independent of cognate intracellular steroid receptors. She is an expert on the effects and mechanisms of neurosteroids, which are steroids that are produced in, and have rapid, paracrine neurotransmitter-like actions in the brain. Because hormones are essential for mating, her research has used reproductive behavior as a bioassay to reveal non-steroid receptor mediated actions and the role and mechanisms by which neurosteroids mediate reproductive behavior and associated neuroendocrine processes. Visit The Frye Lab web site to learn more about her research.

Dr. Frye’s research has been funded by The National Science Foundation, The National Institutes of Health, The Donaghue Foundation, The Whitehall Foundation, The Epilepsy Foundation, and Eli Lilly Centre for Women's Health Research, and The Department of Defense Breast Cancer Research Program. Her research has implications for the efficacy of pregnancy massage and the hormone response in pregnant women, and her team is working with the APMA to devise research protocols around the effects of pregnancy massage.